Flavonoids chemistry biochemistry and applications pdf
Flavonoids | Chemistry, Biochemistry and Applications | Taylor & Francis GroupRecently, MAYV has attracted attention due to its likely urbanization. Currently, there are no licensed drugs against most mosquito-transmitted viruses. Here, we investigated the in vitro anti-MAYV activity of the flavonoids quercetin and its derivatives from the Brazilian shrub Bauhinia longifolia Bong. Flavonoids were purified by chromatographic fractionation from leaf extracts of B. Cytotoxicity of purified flavonoids and of EtOAc- and n -BuOH-containing flavonoid mixtures was measured by the dye-uptake assay while their antiviral activity was evaluated by a virus yield inhibition assay. The following flavonoids were purified from B.
Improving the estimation of flavonoid intake for study of health outcomes
Imprecision in estimating intakes of non-nutrient bioactive compounds such as flavonoids is a challenge in epidemiologic studies of health outcomes. The sources of this imprecision, using flavonoids as an example, include the variability of bioactive compounds in foods due to differences in growing conditions and processing, the challenges in laboratory quantification of flavonoids in foods, the incompleteness of flavonoid food composition tables, and the lack of adequate dietary assessment instruments. Steps to improve databases of bioactive compounds and to increase the accuracy and precision of the estimation of bioactive compound intakes in studies of health benefits and outcomes are suggested. Flavonoids are bioactive, polyphenolic, non-nutrients in plants 1 , 2 that are ubiquitous in diets. Table 1 lists some common food sources of the various flavonoid classes and references figures illustrating some of these Figure 2 and Figures S1—S3 , which are available in the Supporting Information for this article online. Emerging science from some observational and metabolic studies suggests that flavonoid-rich diets may lower the risk of some diet-related chronic degenerative diseases, such as cardiovascular disease, type 2 diabetes, and certain cancers, 12—16 but a few clinical and laboratory reports indicate that very high doses of certain flavonoids may have adverse effects, such as interference with common medications and, for some green tea extracts, liver toxicity.
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